Танниновая кислота обеспечивает быстрое заживление роговицы без образования рубцов путем хелатирования избытка меди для подавления аберрантного LOX-опосредованного фиброза

Tannic Acid Achieves Rapid Scar-Free Corneal Healing by Chelating Excess Copper to Suppress Aberrant LOX-Mediated Fibrosis.

Corneal scarring and fibrosis following injury remain leading causes of visual impairment worldwide.^1,2 The pathogenesis of corneal scarring involves a complex, multi-stage wound healing process requiring precise coordination among epithelial regeneration, stromal remodeling, and extracellular matrix (ECM) reorganization.^3,4 However, corneal wound healing is prone to dysregulation. Excessive myofibroblast activation, aberrant collagen deposition, and pathological matrix remodeling can disrupt normal tissue architecture.^2,5 These pathological processes ultimately result in corneal scarring, opacity, and irreversible vision loss.⁶ Given the substantial clinical burden and irreversible nature of vision loss, identifying novel therapeutic targets and elucidating mechanisms that govern pathological scarring remain critical research imperatives.