121.Biswas S, Munier FL, Yardley J, et al: Missense mutations in COL8A2, the gene encoding the alpha2 chain of type VIII collagen, cause two forms of corneal endothelial dystrophy.  Hum Mol Genet  2001; 10:2415-2423.

122.Laule A, Cable MK, Hoffman CE, et al: Endothelial cell population changes of human cornea during life.  Arch Ophthalmol  1978; 96:2031-2035.

123.Thoft RA, Friend J: The X, Y, Z, hypothesis of corneal epithelial maintenance.  Invest Ophthalmol Vis Sci  1983; 24:1442-1443.

124.Cotsareils G, Cheng S-Z, Dong G, et al: Existence of slow-cycling limbal epithelial basal cells that can be preferentially stimulated to proliferate: implications on epithelial stem cells.  Cell  1989; 57:201-209.

125.Daniels JT, Harris AR, Mason C: Corneal epithelial stem cells in health and disease.  Stem Cell Rev  2006; 2:247-254.

126.O'Sullivan F, Clynes M: Limbal stem cells, a review of their identification and culture for clinical use.  Cytotechnology  2007; 53:101-106.

127.Secker GA, Daniels JT: Corneal epithelial stem cells: deficiency and regulation.  Stem Cell Rev  2008; 4:159-168.

128.Binder PS, Wickham MG, Zavala EY, et al: Corneal anatomy and wound healing.   In: Barraque JI, Binder PS, Buxton JN, et al ed. Symposium on medical and surgical diseases of the cornea,  St. Louis, MO: Mosby; 1980:1-35.

129.Kuwabara T, Perkins DG, Cogan DG: Sliding of the epithelium in experimental corneal wounds.  Invest Ophthalmol Vis Sci  1976; 15:4-14.

130.Buck RC: Cell migration in repair of mouse corneal epithelium.  Invest Ophthalmol Vis Sci  1979; 18:767-784.

131.Hanna C: Proliferation and migration of epithelial cells.  Am J Ophthalmol  1966; 61:55-63.

132.Matsuda H, Smelser GK: Electron microscopy of corneal wound healing.  Exp Eye Res  1973; 16:427-442.

133.Proctor RA: Fibronectin: a brief overview of its structure, function, and physiology.  Rev Infect Dis  1987; 9(suppl 4):S317-S321.

134.Cameron JD, Hagen ST, Waterfield RR, et al: Effects of matrix proteins on rabbit corneal epithelial cell adhesion and migration.  Curr Eye Res  1988; 7:293-301.

135.Nakagawa S, Nishida T, Kodama Y, et al: Spreading of cultured corneal epithelial cells on fibronectin and other extracellular matrices.  Cornea  1990; 9:125-130.

136.Stepp MA, Spurr-Michaud S, Gipson IK: Integrins in the wounded and unwounded stratified squamous epithelium of the cornea.  Invest Ophthalmol Vis Sci  1993; 34:1829-1844.

137.Latvala T, Tervo K, Tervo T: Reassembly of the α6β4 integrin and laminin in rabbit corneal basement membrane after excimer laser surgery: a 12-month follow-up.  CLAO J  1995; 21:125-129.

138.Itano N: Simple primary structure, complex turnover regulation and multiple roles of hyaluronan.  J Biochem  2008; 144:131-137.

139.Fitzsimmons TD, Fagerholm P, Harfstrand A, et al: Hyaluronic acid in the rabbit cornea after excimer laser superficial keratectomy.  Invest Ophthalmol Vis Sci  1992; 33:3011-3016.

140.Fagerholm P, Fitzsimmons T, Harfstrand A, et al: Reactive formation of hyaluronic acid in the rabbit corneal alkali burn.  Acta Ophthalmol Suppl (Copenh)  1992; 202:67-72.

141.Nakamura M, Hikida M, Nakano T: Concentration and molecular weight dependency of rabbit corneal epithelial wound healing on hyaluronan.  Curr Eye Res  1992; 11:981-986.

142.Nakamura M, Sato N, Chikama TI, et al: Hyaluronan facilitates corneal epithelial wound healing in diabetic rats.  Exp Eye Res  1997; 64:1043-1050.

143.Nakamura M, Nishida T: Recent developments in the use of hyaluronan in wound healing.  Exp Opin Invest Drugs  1995; 4:175-188.

144.Nishida T, Nakamura M, Mishima H, et al: Hyaluronan stimulates corneal epithelial migration.  Exp Eye Res  1991; 53:753-758.

145.Salonen E-M, Tervo T, Torma E, et al: Plasmin in tear fluid of patients with corneal ulcers: basis for new therapy.  Acta Ophthalmol  1987; 65:3-12.

146.Hayashi K, Sueishi K: Fibrinolytic activity and species of plasminogen activator in human tears.  Exp Eye Res  1988; 46:131-137.

147.Sivak JM, Fini ME: MMPs in the eye: emerging roles for matrix metalloproteinases in ocular physiology.  Prog Retin Eye Res  2002; 21:1-14.

148.Barrientos S, Stojadinovic O, Golinko MS, et al: Growth factors and cytokines in wound healing.  Wound Repair Regen  2008; 16:585-601.

149.Cohen S: Isolation of a mouse submaxillary gland protein accelerating incisor eruption and eyelid opening in the new-born animal.  J Biol Chem  1962; 237:1555-1562.

150.Frati L, Daniele S, Delogu A, et al: Selective binding of the epidermal growth factor and its specific effects on the epithelial cells of the cornea.  Exp Eye Res  1972; 14:135-141.

151.Savage CRJ, Cohen S: Proliferation of corneal epithelium induced by epidermal growth factor.  Exp Eye Res  1973; 15:361-366.

152.Ho PC, Davis WH, Elliott JH, et al: Kinetics of corneal epithelial regeneration and epidermal growth factor.  Invest Ophthalmol Vis Sci  1974; 13:804-809.

153.Gonul B, Koz M, Ersoz G, et al: Effect of EGF on the corneal wound healing of alloxan diabetic mice.  Exp Eye Res  1992; 54:519-524.

154.Nishida T, Nakamura M, Murakami J, et al: Epidermal growth factor stimulates corneal epithelial cell attachment to fibronectin through a fibronectin receptor system.  Invest Ophthalmol Vis Sci  1992; 33:2464-2469.

155.Nishida T, Nakamura M, Mishima H, et al: Differential modes of action of fibronectin and epidermal growth factor on rabbit corneal epithelial migration.  J Cell Physiol  1990; 145:549-554.

156.Wilson SE, Lloyd SA, He YG: EGF, basic FGF, and TGFβ-1 messenger RNA production in rabbit corneal epithelial cells.  Invest Ophthalmol Vis Sci  1992; 33:1987-1995.

157.Roberts AB, Russo A, Felici A, et al: Smad3: a key player in pathogenetic mechanisms dependent on TGF-β.  Ann NY Acad Sci  2003; 995:1-10.

158.Mishima H, Nakamura M, Murakami J, et al: Transforming growth factor-β modulates effects of epidermal growth factor on corneal epithelial cells.  Curr Eye Res  1992; 11:691-696.

159.Steiling H, Werner S: Fibroblast growth factors: key players in epithelial morphogenesis, repair and cytoprotection.  Curr Opin Biotechnol  2003; 14:533-537.

160.Rieck P, Assouline M, Savoldelli M, et al: Recombinant human basic fibroblast growth factor (Rh-bFGF) in three different wound models in rabbits: corneal wound healing effect and pharmacology.  Exp Eye Res  1992; 54:987-998.

161.Knorr M, Steuhl K, Tatje D, et al: A rabbit corneal epithelial cell line expresses functional platelet-derived growth factor β-type receptors.  Invest Ophthalmol Vis Sci  1992; 33:2207-2211.

162.Steinke JW, Borish L: 3. Cytokines and chemokines.  J Allergy Clin Immunol  2006; 117:S441-S445.

163.Wilson SE, Liu JJ, Mohan RR: Stromal-epithelial interactions in the cornea.  Prog Retin Eye Res  1999; 18:293-309.

164.Sakamoto S, Inada K, Chiba K, et al: Production of IL-6 and IL-1a by human corneal epithelial cells.  Acta Soc Ophthalmol Jpn  1991; 95:728-732.

165.Nishida T, Nakamura M, Mishima H, et al: Interleukin 6 facilitates corneal epithelial wound closure in vivo.  Arch Ophthalmol  1992; 110:1292-1294.

166.Ohashi H, Maeda T, Mishima H, et al: Up-regulation of integrin α5β1 expression by interleukin-6 in rabbit corneal epithelial cells.  Exp Cell Res  1995; 218:418-423.

167.Bisla K, Tanelian DL: Concentration-dependent effects of lidocaine on corneal epithelial wound healing.  Invest Ophthalmol Vis Sci  1992; 33:3029-3033.

168.Pernow B, Substance P: Pharmacol Rev  1983; 35:85-141.

169.McGillis JP, Organist ML, Payan DG: Substance P and immunoregulation.  Fed Proc  1987; 46:196-199.

170.Payan DG: Neuropeptides and inflammation: the role of substance P.  Annu Rev Med  1989; 40:341-352.

171.Wallengren J, Hakanson R: Effects of substance P, neurokinin A and calcitonin gene-related peptide in human skin and their involvement in sensory nerve-mediated responeses.  Eur J Pharmacol  1987; 143:267-273.

172.Shimizu Y: Localization of neuropeptides in the cornea and uvea of the rat: an immunohistochemical study.  Cell Mol Biol  1982; 28:103-110.

173.Nishiyama A, Masuda K, Mochizuki M: Ocular effects of substance P.  Jpn J Ophthalmol  1981; 25:362-369.

174.Cook GA, Elliott D, Metwali A, et al: Molecular evidence that granuloma T lymphocytes in murine Schistosomiasis mansoni express an authentic substance P (NK-1) receptor.  J Immunol  1994; 152:1830-1835.

175.Kaplan JE: Plasma fibronectin and resistance to thrombosis during sepsis.  Adv Shock Res  1982; 7:159-172.

176.Brown SM, Lamberts DW, Reid TW, et al: Neurotrophic and anhidrotic keratopathy treated with substance P and insulinlike growth factor 1.  Arch Ophthalmol  1997; 115:926-927.

177.Chikama T, Fukuda K, Morishige N, et al: Treatment of neurotrophic keratopathy with substance-P-derived peptide (FGLM) and insulin-like growth factor I.  Lancet  1998; 351:1783-1784.

178.Morishige N, Komatsubara T, Chikama T, et al: Direct observation of corneal nerve fibres in neurotrophic keratopathy by confocal biomicroscopy.  Lancet  1999; 354:1613-1614.

179.Levi-Montalcini R: The nerve growth factor 35 years later.  Science  1987; 237:1154-1162.

180.Rask CA: Biological actions of nerve growth factor in the peripheral nervous system.  Eur Neurol  1999; 41(suppl 1):14-19.

181.Levi-Montalcini R, Hamburger V: A diffusible agent of mouse sarcoma producing hyperplasia of sympathic ganglia and hyperneurotization of the chick embryo.  J Exp Zool  1953; 123:233-388.