Кросслинкинг коллагена при кератоконусе: механизмы клеточной сигнализации

Keratoconus (KC) is a common ectatic corneal dystrophy that causes thinning, bulging, and scarring of the human cornea [¹]. While the disease progression and severity can vary significantly among individuals, it is estimated that approximately 1:400 people are affected worldwide [²]. The first KC treatments described relied on concave lenses or the equivalent hard contact lens used today in order to correct refractive errors. It was posited in these early studies that structural defects in the central cornea led to the formation of a cone centrally due to normal intraocular pressure. Though the cause of KC is still unknown today, these early clinical studies describe similar medical approaches compared to modern times in the treatment of KC.