Полногеномное секвенирование в рамках полногеномного поиска ассоциаций в <i>All of Us</i> выявляет новый локус риска глаукомы у лиц африканского происхождения.

A Whole-Genome Sequence Genome-Wide Association Study in <i>All of Us</i> Identifies a Novel Glaucoma Risk Locus in African Individuals.

While primary open-angle glaucoma (POAG) is prevalent in all populations, population-based studies suggest it disproportionately affects African and Latino individuals, who have a younger age at onset, present at more advanced disease stages, and have greater risk of blindness compared to non-Hispanic Whites.¹, ², ³, ⁴, ⁵ More than 300 risk loci have been identified in prior analyses of this highly heritable complex disease,⁶, ⁷, ⁸ which have mainly been conducted in individuals of European (EUR) ancestry. However, few are conclusively associated with risk of glaucoma in individuals of African (AFR) continental genetic ancestry,⁹, ¹⁰, ¹¹, ¹², ¹³, ¹⁴ and even fewer in those with Latino/Admixed American (AMR) ancestry.^10,14